Dry Eye Disease is a challenging disease of the ocular surface that causes eye pain, inflammation, and difficulty dealing with daily tasks.
Glaucoma is a slow acting disease, and damage is irreversible. Proper diagnosis and intervention is critical.
Imagine you are looking at a clock with hands. With Dry Age-Related Macular Degeneration (Dry AMD), you might see the clock’s numbers, but not the hands.
Stuart Therapeutics (Stuart) is a clinical stage biopharmaceutical company focused on the development of a unique tissue reparative platform for eye diseases called PolyColTM (PolyCol). PolyCol is a family of synthesized polypeptide sequences that are specifically designed to repair damaged extracellular matrix (ECM) helical collagen. Helical collagen structures play an important role in healthy tissues and they are damaged in chronic and acute/traumatic disease processes and injuries.
Stuart was founded in 2018 to champion a new approach to the treatment of chronic diseases. Each of our founders has been affected directly or indirectly by chronic eye disease, and we have a passion for the pursuit of new and effective solutions for these indications.
Stuart’s areas of interest are Dry Eye Disease, Glaucoma, and Dry Age-Related Macular Degeneration.
Chronic eye diseases threaten visual function, and ultimately, sight itself. This loss impacts our ability to enjoy the activities and images that create our “futures.” Stuart Therapeutics exists to preserve those futures.
The ECM is a three-dimensional network consisting of macromolecules including collagen, the most abundant protein in the human body.
Collagen in the Eye
Collagen plays both a structural and cell signaling role in the human eye. Collagen signaling controls cell growth, proliferation and inflammation.
A major form of collagen is the triple helix, formed by three complex amino acid chains bound together by electrochemical forces.
Collagenases are enzymes that break the peptide bonds in collagen. They are involved in degrading and remodeling extracellular structures.